The Spain youth international found the net in the 45th minute to open the scoring at the Juventus Stadium.
Alexandre Pato – who now represents Orlando City in Major League Soccer – achieved his mark on December 14, 2008, in the Red and Blacks’ 4-2 loss to the Old Lady while he was 19 years and 103 days old.
However, they lost all three points at stake against their impressive visitors.
Twelve minutes into the second half, Milan had the chance to double their lead from the spot following Giorgio Chiellini’s handball in the area, but Szczesny was well placed to save Franck Kessie’s poor penalty.
In the 68th minute, Ronaldo completed a couple of step-overs inside the penalty area to work some room, before curling an effort to the far post which missed the target by a significant distance.
Super-sub Ante Rebic sealed the win for the visiting side in the 78th minute. The striker received Ismael Bennacer’s pass in space on the edge of the penalty area in-between two centre-backs, before unleashing a powerful strike past Szczesny.
Four minutes later, England international of Nigerian origin Fikayo Tomori completed the defeat.